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Here are some animals you don't want to upset. Since many animals could claim the title "meanest," this list is subjective rather than authoritative.
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Simplified Content Type
Ratel

Land mammal

The ratel, or honey badger, is one of the fiercest, most predatory animals on the planet. They prey upon many animals, including scorpions, porcupines, tortoises, crocodiles, and snakes. Attracted to honey, they also ravage beehives. Healthy ratels have no predators; their viciousness and loose skin, which make them difficult to grip, keep other animals at a distance.
Leopard seal

Marine Mammal

Leopard seals and killer whales are the most predatory of all marine mammals. Leopard seals have been known to seek out human victims. Killer whales are the only mammals that prey on leopard seals. Leopard seals, which are earless animals, inhabit Antarctic and sub-Antarctic waters.
Peregrine falcon

Bird

The peregrine falcon, a fiercely aggressive hunter, preys on small mammals and other birds. It descends on its victims from the air at speeds of up to 200 m.p.h. Falcons don't build nests. Instead, they lay their eggs on the ground, on the ledges of cliffs, or in abandoned nests of other birds.
stonefish

Fish

The stonefish, which lives at the bottom of the ocean, is the most poisonous fish in the world. Its 13 dorsal spines release deadly venom, making it dangerous to both humans and marine life.
Inland taipan

Reptile

One bite from the inland taipan, a shy snake contains enough toxin to kill about 100 people. This deadly snake is native to central Australia and lives in holes, feeding on small rodents and birds.
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